The Human Upgrade

Dave Asprey built Bulletproof Coffee into a household name and parlayed that into becoming one of the most recognizable figures in biohacking. The Human Upgrade is his flagship podcast, running since 2013 with over 1,500 episodes and nearly 7,000 ratings. The show drops four times a week -- Tuesday, Thursday, Friday, and a Sunday bonus -- which means there is always new content, sometimes more than you can keep up with. The guest roster reads like a directory of longevity and performance science: stem cell researchers, thyroid specialists, gut microbiome experts, neuroplasticity scientists, and detoxification researchers. Recent episodes cover autophagy and cellular aging, vision restoration through non-surgical methods, and the real metabolic effects of GLP-1 drugs. Asprey mixes solo teaching episodes (where he synthesizes research into actionable protocols) with long-form interviews that can run anywhere from 13 minutes to over an hour. Asprey is polarizing, and the show reflects that. He speaks with enormous confidence about topics where the scientific consensus is still forming, and he openly promotes products and therapies that mainstream medicine views with skepticism. Some listeners find that visionary; others find it reckless. The truth is probably somewhere in between. At his best, Asprey surfaces ideas and researchers that take years to reach mainstream awareness. At his worst, the line between education and advertisement gets blurry. The 4.6 rating suggests most listeners land on the favorable side. If you can engage critically with the material rather than taking every recommendation at face value, the show is a genuinely rich source of health optimization ideas.