Depresh Mode with John Moe

John Moe has been doing this longer than almost anyone in the podcast-mental-health space, and it shows. After his acclaimed Hilarious World of Depression wrapped in 2020, he launched Depresh Mode on the Maximum Fun network and kept right on going. The format is straightforward: hour-long conversations with comedians, musicians, actors, and authors about their real experiences with depression, anxiety, PTSD, and other conditions. What sets it apart is Moe's interviewing style. He's warm without being saccharine, funny without making light of the subject, and genuinely curious about what actually helped his guests and what flopped. You'll hear from people like Maria Bamford, Gary Gulman, and lesser-known voices who are equally compelling. With 270 episodes and a 4.9 rating from over 800 reviews, the show clearly resonates with a wide audience. Moe also regularly brings on therapists and researchers to talk treatment options, grounding the personal stories with clinical perspective. Every episode includes crisis hotline information in the show notes, a small detail that says a lot about how seriously the show takes its responsibility to listeners. Episodes drop weekly and typically run about an hour, which gives conversations room to breathe. If you want a podcast that treats depression as a real, manageable condition rather than something to whisper about, this is probably the best one out there right now.